Sensitive

Alzheimer's disease

TREML2 · rs9394766

Where this position leads

Condition: Alzheimer's Disease Risk (APOE)

rs9394766 Condition: Alzheimer's Disease Risk (APOE) Alzheimer's Disease Risk (APOE) Condition rs9394766 rs9394766 TREML2

What the study found

Who was studied 93,263 European ancestry cases, 532,679 European ancestry controls, 2,748 African ancestry cases, 5,222 African ancestry controls, 3,962 East Asian ancestry cases, 4,074 East Asian ancestry controls, 1,088 Hispanic or Latin American cases, 1,152 Hispanic or Latin American controls.

The effect The reported allele is A; the catalogue records no effect size ; p = 2 × 10−14.

Where it sits Chromosome 6, band 6p21.1 — in the 3′ untranslated region of TREML2.

What each result means

A/A Two copies of the version the research linked to Alzheimer's disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Alzheimer's disease. That is a smaller link than two copies.
G/G No copy of the version the research linked to Alzheimer's disease. This is the starting point the study compared everyone against.
Source

Questions about rs9394766

What is rs9394766?

rs9394766 is a single position in the genome, in or near the TREML2 gene. Published research associates it with alzheimer's disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs9394766 linked to?

On MyGeneLog this position is linked to Alzheimer's Disease Risk (APOE). The research behind each link, and its sources, are set out on that condition page.

Does having rs9394766 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs9394766 come from?

GWAS Catalog, Molecular psychiatry 2023, PMID:37198259. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Alzheimer's disease (rs9394766). MyGeneLog™. https://www.mygenelog.com/variants/rs9394766

← See all variants