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Anxiety

MMS22L · rs9387216

Where this position leads

What the study found

Who was studied at least 23,606 European ancestry cases, at least 113,351 European ancestry controls; replicated in 624,615 European ancestry cases, 1,310,854 European ancestry controls.

The effect Each copy of the C allele shifted the measure 0.0152 higher (95% confidence interval 0.0093-0.0211); p = 9 × 10⁻⁹.

How common The C allele had a frequency of about 23% in the people studied.

Where it sits Chromosome 6, band 6q16.1 — in an intron of MMS22L.

What each result means

A/A Published research associates this genotype with typical/baseline likelihood of Anxiety — no copies of the reported risk allele.

A/C Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Anxiety.

C/C Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Anxiety compared to the general population.

Source

Symptom-level modelling unravels the shared genetic architecture of anxiety and depression

Thorp JG, Campos AI, Grotzinger AD, Gerring ZF, An J, Ong JS, Wang W, Shringarpure S, Byrne EM, MacGregor S, Martin NG, Medland SE

and 2 more — show all

Middeldorp CM, Derks EM

23andMe Research Team

Nature human behaviour · 2021 · PMID 33859377

Questions about rs9387216

What is rs9387216?

rs9387216 is a single position in the genome, in or near the MMS22L gene. Published research associates it with anxiety. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs9387216 linked to?

On MyGeneLog this position is linked to Anxiety Disorder. The research behind each link, and its sources, are set out on that condition page.

Does having rs9387216 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs9387216 come from?

GWAS Catalog, Nature human behaviour 2021, PMID:33859377. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Anxiety (rs9387216). MyGeneLog™. https://www.mygenelog.com/variants/rs9387216

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