Sensitive

BRCA1/2-negative high-risk breast cancer

CCDC170 · rs9383936

Where this position leads

What the study found

Who was studied 1,469 Korean ancestry cases, 5,979 Korean ancestry controls.

The effect Each copy of the A allele carried 1.35 times the odds of BRCA1/2-negative high-risk breast cancer (95% confidence interval 1.23-1.48); p = 1 × 10⁻¹⁰.

How common The A allele had a frequency of about 34% in the people studied.

Where it sits Chromosome 6, band 6q25.1 — between genes, 2.3 kb from CCDC170.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of BRCA1/2-negative high-risk breast cancer compared to the general population.

A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with BRCA1/2-negative high-risk breast cancer.

G/G Published research associates this genotype with typical/baseline likelihood of BRCA1/2-negative high-risk breast cancer — no copies of the reported risk allele.

Source

BRCA1/2-negative, high-risk breast cancers (BRCAX) for Asian women: genetic susceptibility loci and their potential impacts

Lee JY, Kim J, Kim SW, Park SK, Ahn SH, Lee MH, Suh YJ, Noh DY, Son BH, Cho YU, Lee SB, Lee JW

and 2 more — show all

Hopper JL, Sung J

Scientific reports · 2018 · PMID 30323354 · open access

Questions about rs9383936

What is rs9383936?

rs9383936 is a single position in the genome, in or near the CCDC170 gene. Published research associates it with brca1/2-negative high-risk breast cancer. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs9383936 linked to?

On MyGeneLog this position is linked to Breast Cancer. The research behind each link, and its sources, are set out on that condition page.

Does having rs9383936 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs9383936 come from?

GWAS Catalog, Sci Rep 2018, PMID:30323354. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

BRCA1/2-negative high-risk breast cancer (rs9383936). MyGeneLog™. https://www.mygenelog.com/variants/rs9383936

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