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Morbid obesity (PheCode 278.11)

near DNAH8 · rs9380823

Where this position leads

Condition: Obesity and Body Weight

rs9380823 Condition: Obesity and Body Weight Obesity and Body Weight Condition rs9380823 rs9380823 near DNAH8

What the study found

Who was studied 14,258 African American or Afro-Caribbean cases, 101,561 African American or Afro-Caribbean controls, 5,871 Hispanic or Latin American cases, 51,265 Hispanic or Latin American controls, 202 East Asian ancestry cases, 6,509 East Asian ancestry controls, 45,933 European ancestry cases, 385,784 European ancestry controls.

The effect Each copy of the G allele shifted the measure 0.0544 higher (95% confidence interval 0.038-0.071); p = 5 × 10−12.

How common The G allele had a frequency of about 72% in the people studied.

Where it sits Chromosome 6, band 6p21.2 — between genes, 1.8 kb from DNAH8.

What each result means

G/G Two copies of the version the research linked to Morbid obesity (PheCode 278.11). That is the strongest link of the three results. A link in a study is not a diagnosis.
G/T One copy of the version the research linked to Morbid obesity (PheCode 278.11). That is a smaller link than two copies.
T/T No copy of the version the research linked to Morbid obesity (PheCode 278.11). This is the starting point the study compared everyone against.
Source
Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program
Verma A, Huffman JE, Rodriguez A, Conery M, Liu M, Ho YL, Kim Y, Heise DA, Guare L, Panickan VA, Garcon H, Linares F
and 59 more — show all
Costa L, Goethert I, Tipton R, Honerlaw J, Davies L, Whitbourne S, Cohen J, Posner DC, Sangar R, Murray M, Wang X, Dochtermann DR, Devineni P, Shi Y, Nandi TN, Assimes TL, Brunette CA, Carroll RJ, Clifford R, Duvall S, Gelernter J, Hung A, Iyengar SK, Joseph J, Kember R, Kranzler H, Kripke CM, Levey D, Luoh SW, Merritt VC, Overstreet C, Deak JD, Grant SFA, Polimanti R, Roussos P, Shakt G, Sun YV, Tsao N, Venkatesh S, Voloudakis G, Justice A, Begoli E, Ramoni R, Tourassi G, Pyarajan S, Tsao P, O'Donnell CJ, Muralidhar S, Moser J, Casas JP, Bick AG, Zhou W, Cai T, Voight BF, Cho K, Gaziano JM, Madduri RK, Damrauer S, Liao KP
Science (New York, N.Y.) · 2024 · PMID 39024449 · open access

Questions about rs9380823

What is rs9380823?

rs9380823 is a single position in the genome, in or near the near DNAH8 gene. Published research associates it with morbid obesity (phecode 278.11). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs9380823 linked to?

On MyGeneLog this position is linked to Obesity and Body Weight. The research behind each link, and its sources, are set out on that condition page.

Does having rs9380823 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs9380823 come from?

GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Morbid obesity (PheCode 278.11) (rs9380823). MyGeneLog™. https://www.mygenelog.com/variants/rs9380823

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