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Psoriasis vulgaris

near POLR1H · rs9380151

Where this position leads

Condition: Psoriasis

rs9380151 Condition: Psoriasis Psoriasis Condition rs9380151 rs9380151 near POLR1H

What the study found

Who was studied 1,415 Japanese ancestry cases, 3,968 Japanese ancestry controls.

The effect Each copy of the C allele carried 3.68 times the odds of Psoriasis vulgaris (95% confidence interval 3.14-4.31); p = 2 × 10−58.

How common The C allele had a frequency of about 5% in the people studied.

Where it sits Chromosome 6, band 6p22.1 — in an intron of POLR1HASP.

What each result means

C/C Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Psoriasis vulgaris compared to the general population.
C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Psoriasis vulgaris.
T/T Published research associates this genotype with typical/baseline likelihood of Psoriasis vulgaris — no copies of the reported risk allele.
Source
Whole-genome sequencing reveals rare and structural variants contributing to psoriasis and identifies CERCAM as a risk gene
Sonehara K, Watanabe R, Matsumura Y, Mitsui Y, Ogawa Y, Odomari K, Sakaue S, Namba S, Komuro M, Edamoto M, Watanabe J, Hirota T
and 59 more — show all
Arase N, Nakamura Y, Nakajima K, Okamoto T, Nishikawa R, Yamamoto K, Suzuki K, Kishikawa T, Edahiro R, Shirai Y, Naito T, Sasa N, Ishitsuka Y, Furuta J, Kunimoto K, Kajihara I, Fukushima S, Miyachi H, Matsue H, Kamata M, Momose M, Miyagawa I, Tanaka H, Ueno M, Bito T, Nagai H, Ikeda T, Horikawa T, Adachi A, Matsubara T, Nishida E, Matsuda K, Shojima N, Nakagawa I, Asano Y, Sato S, Imafuku S, Tada Y, Nishigori C, Jinnin M, Ihn H, Asahina A, Saeki H, Yamauchi T, Kadowaki T, Kawamura T, Shimada S, Katayama I, Higasa K, Noguchi E, Sano S, Tanaka Y, Matsuda F, Kumanogoh A, Tamari M, Satoh T, Fujimoto M, Morita A, Okada Y
Biobank Japan Project
Cell genomics · 2025 · PMID 40848718 · open access

Questions about rs9380151

What is rs9380151?

rs9380151 is a single position in the genome, in or near the near POLR1H gene. Published research associates it with psoriasis vulgaris. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs9380151 linked to?

On MyGeneLog this position is linked to Psoriasis. The research behind each link, and its sources, are set out on that condition page.

Does having rs9380151 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs9380151 come from?

GWAS Catalog, Cell genomics 2025, PMID:40848718. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Psoriasis vulgaris (rs9380151). MyGeneLog™. https://www.mygenelog.com/variants/rs9380151

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