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Its strongest genetic-study result is p = 10−17, with 1 associations in the GWAS Catalog.
How this is scored
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 645 African American or Afro-Caribbean cases, 120,867 African American or Afro-Caribbean controls, 1,263 European ancestry cases, 449,492 European ancestry controls, 368 Hispanic or Latin American cases, 59,392 Hispanic or Latin American controls.
The effect
Each copy of the C allele shifted the measure 0.373 lower (95% confidence interval 0.32-0.43); p = 5 × 10−18.
How common The C allele had a frequency of about 75% in the people studied.
Where it sits Chromosome 6, band 6p22.1 — between genes, 3.1 kb from HLA-G.
What each result means
C/CTwo copies of the version the research linked to Vitiligo (PheCode 694.1). That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Vitiligo (PheCode 694.1). That is a smaller link than two copies.
T/TNo copy of the version the research linked to Vitiligo (PheCode 694.1). This is the starting point the study compared everyone against.
Science (New York, N.Y.) · 2024 · PMID 39024449 · open access
Questions about rs9380143
What is rs9380143?
rs9380143 is a single position in the genome, in or near the near HLA-G gene. Published research associates it with vitiligo (phecode 694.1). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs9380143 linked to?
On MyGeneLog this position is linked to Vitiligo. The research behind each link, and its sources, are set out on that condition page.
Does having rs9380143 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs9380143 come from?
GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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