Standard

Chronic obstructive asthma (PheCode 495.1)

near HLA-DQA1 · rs9368731

Where this position leads

Condition: Asthma

rs9368731 Condition: Asthma Asthma Condition rs9368731 rs9368731 near HLA-DQA1

What the study found

Who was studied 1,031 African American or Afro-Caribbean cases, 119,552 African American or Afro-Caribbean controls, 4,059 European ancestry cases, 442,153 European ancestry controls, 390 Hispanic or Latin American cases, 59,020 Hispanic or Latin American controls.

The effect Each copy of the A allele shifted the measure 0.259 lower (95% confidence interval 0.21-0.31); p = 8 × 10−14.

How common The A allele had a frequency of about 72% in the people studied.

Where it sits Chromosome 6, band 6p21.32 — between genes, 1.1 kb from HLA-DQA1.

What each result means

A/A Two copies of the version the research linked to Chronic obstructive asthma (PheCode 495.1). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Chronic obstructive asthma (PheCode 495.1). That is a smaller link than two copies.
G/G No copy of the version the research linked to Chronic obstructive asthma (PheCode 495.1). This is the starting point the study compared everyone against.
Source

Questions about rs9368731

What is rs9368731?

rs9368731 is a single position in the genome, in or near the near HLA-DQA1 gene. Published research associates it with chronic obstructive asthma (phecode 495.1). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs9368731 linked to?

On MyGeneLog this position is linked to Asthma. The research behind each link, and its sources, are set out on that condition page.

Does having rs9368731 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs9368731 come from?

GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Chronic obstructive asthma (PheCode 495.1) (rs9368731). MyGeneLog™. https://www.mygenelog.com/variants/rs9368731

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