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Atopic dermatitis

HLA-C · rs9368677

Where this position leads

Strength of the evidence

1 / 4

Its strongest genetic-study result is p = 10⁻¹⁷, with 1 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10⁻⁵⁰. 2: ClinVar from one lab (1 star), or p ≤ 10⁻²⁰. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10⁻⁸). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 1,472 Japanese ancestry cases, 7,971 Japanese ancestry controls; replicated in 1,856 Japanese ancestry cases, 7,021 Japanese ancestry controls.

The effect Each copy of the G allele carried 1.36 times the odds of Atopic dermatitis (95% confidence interval 1.27-1.46); p = 1 × 10⁻¹⁷.

How common The G allele had a frequency of about 80% in the people studied.

Where it sits Chromosome 6, band 6p21.33 — in an intron of LOC112267902.

How common each version is

AG

Korean KRGDB

A 16.7% · G 83.3%

Korean Korea4K

A 16.2% · G 83.8%

Japanese ToMMo

A 18.4% · G 81.6%

Vietnamese

A 18.3% · G 81.7%

World gnomAD

A 7.7% · G 92.3%

World 1000 Genomes

A 10.8% · G 89.2%

World TOPMed

A 7.8% · G 92.2%

The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study.

What each result means

A/A No copy of the version the research linked to Atopic dermatitis. This is the starting point the study compared everyone against.

A/G One copy of the version the research linked to Atopic dermatitis. That is a smaller link than two copies.

G/G Two copies of the version the research linked to Atopic dermatitis. That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population

Hirota T, Takahashi A, Kubo M, Tsunoda T, Tomita K, Sakashita M, Yamada T, Fujieda S, Tanaka S, Doi S, Miyatake A, Enomoto T

and 18 more — show all

Nishiyama C, Nakano N, Maeda K, Okumura K, Ogawa H, Ikeda S, Noguchi E, Sakamoto T, Hizawa N, Ebe K, Saeki H, Sasaki T, Ebihara T, Amagai M, Takeuchi S, Furue M, Nakamura Y, Tamari M

Nature genetics · 2012 · PMID 23042114

Questions about rs9368677

What is rs9368677?

rs9368677 is a single position in the genome, in or near the HLA-C gene. Published research associates it with atopic dermatitis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs9368677 linked to?

On MyGeneLog this position is linked to Atopic Dermatitis. The research behind each link, and its sources, are set out on that condition page.

Does having rs9368677 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs9368677 come from?

GWAS Catalog, Nat Genet 2012, PMID:23042114. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Atopic dermatitis (rs9368677). MyGeneLog™. https://www.mygenelog.com/variants/rs9368677

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