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Sensitive

Broad depression or major depressive disorder (self-reported)

MUC21 · rs9368649

Where this position leads

Condition: Major Depressive Disorder

rs9368649 Condition: Major Depressive Disorder Major Depressive Disorder Condition rs9368649 rs9368649 MUC21

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Broad depression or major depressive disorder (self-reported) compared to the general population.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Broad depression or major depressive disorder (self-reported).
G/G Published research associates this genotype with typical/baseline likelihood of Broad depression or major depressive disorder (self-reported) — no copies of the reported risk allele.
Source
Bivariate genome-wide association analyses of the broad depression phenotype combined with major depressive disorder, bipolar disorder or schizophrenia reveal eight novel genetic loci for depression
Amare AT, Vaez A, Hsu YH, Direk N, Kamali Z, Howard DM, McIntosh AM, McIntosh AM, Tiemeier H, Bültmann U, Snieder H, Hartman CA
Molecular psychiatry · 2020 · PMID 30626913 · open access

Questions about rs9368649

What is rs9368649?

rs9368649 is a single position in the genome, in or near the MUC21 gene. Published research associates it with broad depression or major depressive disorder (self-reported). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs9368649 linked to?

On MyGeneLog this position is linked to Major Depressive Disorder. The research behind each link, and its sources, are set out on that condition page.

Does having rs9368649 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs9368649 come from?

GWAS Catalog, Mol Psychiatry 2019, PMID:30626913. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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