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Standard

High density lipoprotein cholesterol levels

near ZKSCAN8P2 · rs9368561

Strength of the evidence

1 / 4

Its strongest genetic-study result is p = 10−9, with 1 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 1,320,016 European ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.0164 lower (95% confidence interval 0.012-0.021); p = 3 × 10−9.

How common The T allele had a frequency of about 13% in the people studied.

Where it sits Chromosome 6, band 6p22.1 — between genes, 11.1 kb from ZKSCAN8P2.

How common each version is

CT
Korean KRGDB
C 85.8% · T 14.2%
Korean Korea4K
C 86.3% · T 13.7%
Korean Korea1K
C 86.1% · T 13.9%
Japanese ToMMo
C 83.7% · T 16.3%
Vietnamese
C 86.3% · T 13.7%
World gnomAD
C 89.4% · T 10.6%
World 1000 Genomes
C 90.1% · T 9.9%
World TOPMed
C 88.9% · T 11.1%

The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study.

What each result means

C/C No copy of the version the research linked to High density lipoprotein cholesterol levels. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to High density lipoprotein cholesterol levels. That is a smaller link than two copies.
T/T Two copies of the version the research linked to High density lipoprotein cholesterol levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Quoting this page

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High density lipoprotein cholesterol levels (rs9368561). MyGeneLog™. https://www.mygenelog.com/variants/rs9368561

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