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Standard

Height

SENP6 · rs9360921

Strength of the evidence

1 / 4

Its strongest genetic-study result is p = 10−13, with 1 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 133,653 European ancestry individuals; replicated in 50,074 European ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.042 lower; p = 3 × 10−13.

How common The T allele had a frequency of about 89% in the people studied.

Where it sits Chromosome 6, band 6q14.1 — between genes, 30.1 kb from H3P27.

How common each version is

GT
Korean KRGDB
G 4.1% · T 95.9%
Korean Korea4K
G 4.4% · T 95.6%
Korean Korea1K
G 4.5% · T 95.5%
Japanese ToMMo
G 8.4% · T 91.6%
World gnomAD
G 10.8% · T 89.2%
World 1000 Genomes
G 9.6% · T 90.4%
World TOPMed
G 10.4% · T 89.6%

By ancestry gnomAD

East Asian
G 4.0% · T 96.0%
European (non-Finnish)
G 10.6% · T 89.4%
African / African American
G 12.3% · T 87.7%
South Asian
G 10.3% · T 89.7%
Admixed American (Latino)
G 9.3% · T 90.7%
Middle Eastern
G 9.6% · T 90.4%
Finnish
G 12.8% · T 87.2%
Ashkenazi Jewish
G 9.4% · T 90.6%

The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study. The ancestry rows are gnomAD's own groups (via Ensembl), as the survey defines them, not races.

What each result means

G/G No copy of the version the research linked to Height. This is the starting point the study compared everyone against.
G/T One copy of the version the research linked to Height. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Height. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Quoting this page

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Height (rs9360921). MyGeneLog™. https://www.mygenelog.com/variants/rs9360921

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