Gene Knowledge Graph
UTC
Standard

Atopic march

EFHC1 · rs9357733

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 1,151 European ancestry early-onset eczema and childhood asthma cases, 10,030 European ancestry controls; replicated in 1,277 European ancestry early-onset eczema and childhood asthma cases, 7,004 European ancestry controls.

The effect Each copy of the A allele carried 1.27 times the odds of Atopic march (95% confidence interval 1.17-1.38); p = 2 × 10−8.

How common The A allele had a frequency of about 81% in the people studied.

Where it sits Chromosome 6, band 6p12.2 — in an intron of EFHC1.

What each result means

A/A Two copies of the version the research linked to Atopic march. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Atopic march. That is a smaller link than two copies.
G/G No copy of the version the research linked to Atopic march. This is the starting point the study compared everyone against.
Source
Meta-analysis identifies seven susceptibility loci involved in the atopic march
Marenholz I, Esparza-Gordillo J, Rüschendorf F, Bauerfeind A, Strachan DP, Spycher BD, Baurecht H, Margaritte-Jeannin P, Sääf A, Kerkhof M, Ege M, Baltic S
and 61 more — show all
Matheson MC, Li J, Michel S, Ang WQ, McArdle W, Arnold A, Homuth G, Demenais F, Bouzigon E, Söderhäll C, Pershagen G, de Jongste JC, Postma DS, Braun-Fahrländer C, Horak E, Ogorodova LM, Puzyrev VP, Bragina EY, Hudson TJ, Morin C, Duffy DL, Marks GB, Robertson CF, Montgomery GW, Musk B, Thompson PJ, Martin NG, James A, Sleiman P, Toskala E, Rodriguez E, Fölster-Holst R, Franke A, Lieb W, Gieger C, Heinzmann A, Rietschel E, Keil T, Cichon S, Nöthen MM, Pennell CE, Sly PD, Schmidt CO, Matanovic A, Schneider V, Heinig M, Hübner N, Holt PG, Lau S, Kabesch M, Weidinger S, Hakonarson H, Ferreira MAR, Laprise C, Freidin MB, Genuneit J, Koppelman GH, Melén E, Dizier MH, Henderson AJ, Lee YA
Nature communications · 2015 · PMID 26542096 · open access

Questions about rs9357733

What is rs9357733?

rs9357733 is a single position in the genome, in or near the EFHC1 gene. Published research associates it with atopic march. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs9357733 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs9357733 come from?

GWAS Catalog, Nat Commun 2015, PMID:26542096. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Atopic march (rs9357733). MyGeneLog™. https://www.mygenelog.com/variants/rs9357733

← See all variants