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Cholesterol, total

HLA-C · rs9357121

Where this position leads

Condition: Cholesterol (LDL, HDL and Total)

rs9357121 Condition: Cholesterol (LDL, HDL and Total) Cholesterol (LDL, HDL and Total) Condition rs9357121 rs9357121 HLA-C

What the study found

Who was studied 8,344 Han Chinese ancestry individuals; replicated in 14,739 Han Chinese ancestry individuals.

The effect Each copy of the T allele shifted the measure 2.06 higher (95% confidence interval 1.42-2.71); p = 2 × 10−10.

How common The T allele had a frequency of about 85% in the people studied.

Where it sits Chromosome 6, band 6p21.33 — between genes, 0.6 kb from HLA-C.

What each result means

G/G No copy of the version the research linked to Cholesterol, total. This is the starting point the study compared everyone against.
G/T One copy of the version the research linked to Cholesterol, total. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Cholesterol, total. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs9357121

What is rs9357121?

rs9357121 is a single position in the genome, in or near the HLA-C gene. Published research associates it with cholesterol, total. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs9357121 linked to?

On MyGeneLog this position is linked to Cholesterol (LDL, HDL and Total). The research behind each link, and its sources, are set out on that condition page.

Does having rs9357121 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs9357121 come from?

GWAS Catalog, Circ Cardiovasc Genet 2015, PMID:26582766. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Cholesterol, total (rs9357121). MyGeneLog™. https://www.mygenelog.com/variants/rs9357121

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