Sensitive

Coronary artery disease

NR2C1 · rs933899

Where this position leads

Condition: Coronary Artery Disease

rs933899 Condition: Coronary Artery Disease Coronary Artery Disease Condition rs933899 rs933899 NR2C1

What the study found

Who was studied 15,302 Japanese ancestry cases, 36,140 Japanese ancestry controls.

The effect Each copy of the A allele carried 1.15 times the odds of Coronary artery disease (95% confidence interval 1.10-1.20); p = 2 × 10−9.

How common The A allele had a frequency of about 77% in the people studied.

Where it sits Chromosome 12, band 12q22 — in an intron of NR2C1.

What each result means

A/A Two copies of the version the research linked to Coronary artery disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Coronary artery disease. That is a smaller link than two copies.
G/G No copy of the version the research linked to Coronary artery disease. This is the starting point the study compared everyone against.
Source

Questions about rs933899

What is rs933899?

rs933899 is a single position in the genome, in or near the NR2C1 gene. Published research associates it with coronary artery disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs933899 linked to?

On MyGeneLog this position is linked to Coronary Artery Disease. The research behind each link, and its sources, are set out on that condition page.

Does having rs933899 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs933899 come from?

GWAS Catalog, Circulation. Genomic and precision medicine 2020, PMID:32469254. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Coronary artery disease (rs933899). MyGeneLog™. https://www.mygenelog.com/variants/rs933899

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