Broad depression or major depressive disorder (recurrent)
PLEK2 · rs9323497
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Who was studied 9,240 European ancestry broad depression cases, 9,519 European ancestry broad depression controls, 51,258 European ancestry individuals, 5,303 Chinese ancestry recurrent major depressive disorder cases, 5,337 Chinese ancestry recurrent major depressive disorder controls; replicated in 322,580 individuals.
The effect
The reported allele is T; the catalogue records no effect size
; p = 4 × 10−9.
How common The T allele had a frequency of about 5% in the people studied.
Where it sits Chromosome 14, band 14q24.1 — in an intron of PLEK2.
What each result means
C/CNo copy of the version the research linked to Broad depression or major depressive disorder (recurrent). This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Broad depression or major depressive disorder (recurrent). That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Broad depression or major depressive disorder (recurrent). That is the strongest link of the three results. A link in a study is not a diagnosis.
Molecular psychiatry · 2020 · PMID 30626913 · open access
Questions about rs9323497
What is rs9323497?
rs9323497 is a single position in the genome, in or near the PLEK2 gene. Published research associates it with broad depression or major depressive disorder (recurrent). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs9323497 linked to?
On MyGeneLog this position is linked to Major Depressive Disorder. The research behind each link, and its sources, are set out on that condition page.
Does having rs9323497 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs9323497 come from?
GWAS Catalog, Mol Psychiatry 2019, PMID:30626913. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 2715123114Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity1Meta AI5Microsoft · Copilot1Amazon2Apple3China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others14Total27Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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Broad depression or major depressive disorder (recurrent) (rs9323497). MyGeneLog™. https://www.mygenelog.com/variants/rs9323497