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Systolic blood pressure x educational attainment (graduated college) interaction (2df)

LIN01249 · rs9308788

Where this position leads

What the study found

Who was studied 27,367 European ancestry college graduated individuals, 51,673 European ancestry non-college graduated individuals, 3,605 African ancestry college graduated individuals, 13,060 African ancestry non-college graduated individuals, 291 Asian ancestry college graduated individuals, 457 Asian ancestry non-college graduated individuals, 786 Hispanic/Latin American college graduated individuals, 4,359 Hispanic/Latin American non-college graduated individuals; replicated in 67,506 European ancestry college graduated individuals, 189,531 European ancestry non-college graduated individuals, 781 African ancestry college graduated individuals, 6,417 African ancestry non-college graduated individuals, 651 Asian ancestry college graduated individuals, 5,296 Asian ancestry non-college graduated individuals, 1,703 Hispanic college graduated individuals, 9,928 Hispanic non-college graduated individuals.

The effect Each copy of the A allele shifted the measure 11.9 lower (95% confidence interval 6.76-17.10); p = 4 × 10⁻⁸.

Where it sits Chromosome 2, band 2p25.2 — between genes, 7 kb from LINC01249.

What each result means

A/A Two copies of the version the research linked to Systolic blood pressure x educational attainment (graduated college) interaction (2df). That is the strongest link of the three results. A link in a study is not a diagnosis.

A/T One copy of the version the research linked to Systolic blood pressure x educational attainment (graduated college) interaction (2df). That is a smaller link than two copies.

T/T No copy of the version the research linked to Systolic blood pressure x educational attainment (graduated college) interaction (2df). This is the starting point the study compared everyone against.

Source

Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci

de las Fuentes L, Sung YJ, Noordam R, Winkler T, Feitosa MF, Schwander K, Bentley AR, Brown MR, Guo X, Manning A, Chasman DI, Aschard H

and 211 more — show all

Bartz TM, Bielak LF, Campbell A, Cheng CY, Dorajoo R, Hartwig FP, Horimoto ARVR, Li C, Li-Gao R, Liu Y, Marten J, Musani SK, Ntalla I, Rankinen T, Richard M, Sim X, Smith AV, Tajuddin SM, Tayo BO, Vojinovic D, Warren HR, Xuan D, Alver M, Boissel M, Chai JF, Chen X, Christensen K, Divers J, Evangelou E, Gao C, Girotto G, Harris SE, He M, Hsu FC, Kühnel B, Laguzzi F, Li X, Lyytikäinen LP, Nolte IM, Poveda A, Rauramaa R, Riaz M, Rueedi R, Shu XO, Snieder H, Sofer T, Takeuchi F, Verweij N, Ware EB, Weiss S, Yanek LR, Amin N, Arking DE, Arnett DK, Bergmann S, Boerwinkle E, Brody JA, Broeckel U, Brumat M, Burke G, Cabrera CP, Canouil M, Chee ML, Chen YI, Cocca M, Connell J, de Silva HJ, de Vries PS, Eiriksdottir G, Faul JD, Fisher V, Forrester T, Fox EF, Friedlander Y, Gao H, Gigante B, Giulianini F, Gu CC, Gu D, Harris TB, He J, Heikkinen S, Heng CK, Hunt S, Ikram MA, Irvin MR, Kähönen M, Kavousi M, Khor CC, Kilpeläinen TO, Koh WP, Komulainen P, Kraja AT, Krieger JE, Langefeld CD, Li Y, Liang J, Liewald DCM, Liu CT, Liu J, Lohman KK, Mägi R, McKenzie CA, Meitinger T, Metspalu A, Milaneschi Y, Milani L, Mook-Kanamori DO, Nalls MA, Nelson CP, Norris JM, O'Connell J, Ogunniyi A, Padmanabhan S, Palmer ND, Pedersen NL, Perls T, Peters A, Petersmann A, Peyser PA, Polasek O, Porteous DJ, Raffel LJ, Rice TK, Rotter JI, Rudan I, Rueda-Ochoa OL, Sabanayagam C, Salako BL, Schreiner PJ, Shikany JM, Sidney SS, Sims M, Sitlani CM, Smith JA, Starr JM, Strauch K, Swertz MA, Teumer A, Tham YC, Uitterlinden AG, Vaidya D, van der Ende MY, Waldenberger M, Wang L, Wang YX, Wei WB, Weir DR, Wen W, Yao J, Yu B, Yu C, Yuan JM, Zhao W, Zhao W, Zonderman AB, Becker DM, Bowden DW, Deary IJ, Dörr M, Esko T, Freedman BI, Froguel P, Gasparini P, Gieger C, Jonas JB, Kammerer CM, Kato N, Lakka TA, Leander K, Lehtimäki T, Magnusson PKE, Marques-Vidal P, Penninx BWJH, Samani NJ, van der Harst P, Wagenknecht LE, Wu T, Zheng W, Zhu X, Bouchard C, Cooper RS, Correa A, Evans MK, Gudnason V, Hayward C, Horta BL, Kelly TN, Kritchevsky SB, Levy D, Palmas WR, Pereira AC, Province MM, Psaty BM, Ridker PM, Rotimi CN, Tai ES, van Dam RM, van Duijn CM, Wong TY, Rice K, Gauderman WJ, Morrison AC, North KE, Kardia SLR, Caulfield MJ, Elliott P, Munroe PB, Franks PW, Rao DC, Fornage M

Lifelines Cohort Study

Molecular psychiatry · 2021 · PMID 32372009 · open access

Questions about rs9308788

What is rs9308788?

rs9308788 is a single position in the genome, in or near the LIN01249 gene. Published research associates it with systolic blood pressure x educational attainment (graduated college) interaction (2df). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs9308788 linked to?

On MyGeneLog this position is linked to Educational Attainment. The research behind each link, and its sources, are set out on that condition page.

Does having rs9308788 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs9308788 come from?

GWAS Catalog, Molecular psychiatry 2021, PMID:32372009. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Systolic blood pressure x educational attainment (graduated college) interaction (2df) (rs9308788). MyGeneLog™. https://www.mygenelog.com/variants/rs9308788

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