Standard

Body fat percentage

near ZBTB38 · rs9289630

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

Strength of the evidence

1 / 4

Its strongest genetic-study result is p = 10⁻¹⁶, with 3 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10⁻⁵⁰. 2: ClinVar from one lab (1 star), or p ≤ 10⁻²⁰. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10⁻⁸). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 442,278 European ancestry individuals.

The effect Each copy of the C allele shifted the measure 0.012 % higher; p = 5 × 10⁻¹⁷.

How common The C allele had a frequency of about 39% in the people studied.

Where it sits Chromosome 3, band 3q23 — between genes, 10 kb from ZBTB38.

How common each version is

CG

Korean KRGDB

C 15.6% · G 84.4%

Korean Korea4K

C 15.2% · G 84.8%

Japanese ToMMo

C 17.1% · G 82.9%

Vietnamese

C 17.1% · G 82.9%

World gnomAD

C 43.9% · G 56.1%

World 1000 Genomes

C 39.3% · G 60.7%

World TOPMed

C 45.5% · G 54.5%

The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study.

What each result means

C/C Two copies of the version the research linked to Body fat percentage. That is the strongest link of the three results. A link in a study is not a diagnosis.

C/G One copy of the version the research linked to Body fat percentage. That is a smaller link than two copies.

G/G No copy of the version the research linked to Body fat percentage. This is the starting point the study compared everyone against.

Source

Genetic Evidence for Different Adiposity Phenotypes and Their Opposing Influences on Ectopic Fat and Risk of Cardiometabolic Disease

Martin S, Cule M, Basty N, Tyrrell J, Beaumont RN, Wood AR, Frayling TM, Sorokin E, Whitcher B, Liu Y, Bell JD, Thomas EL

and 1 more — show all

Yaghootkar H

Diabetes · 2021 · PMID 33980691

Questions about rs9289630

What is rs9289630?

rs9289630 is a single position in the genome, in or near the near ZBTB38 gene. Published research associates it with body fat percentage. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs9289630 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs9289630 come from?

GWAS Catalog, Diabetes 2021, PMID:33980691. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license

Body fat percentage (rs9289630). MyGeneLog™. https://www.mygenelog.com/variants/rs9289630

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