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Chronic hepatitis B infection

HLA-DPB1 · rs9277562

Where this position leads

Condition: Chronic Hepatitis B

rs9277562 Condition: Chronic Hepatitis B Chronic Hepatitis B Condition rs9277562 rs9277562 HLA-DPB1

What the study found

Who was studied 2,234 East Asian ancestry cases, 169,588 East Asian ancestry controls.

The effect Each copy of the T allele shifted the measure 0.44 higher (95% confidence interval 0.38-0.5); p = 5 × 10−45.

How common The T allele had a frequency of about 58% in the people studied.

Where it sits Chromosome 6, band 6p21.32 — in the 3′ untranslated region of HLA-DPB1.

What each result means

C/C No copy of the version the research linked to Chronic hepatitis B infection. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Chronic hepatitis B infection. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Chronic hepatitis B infection. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs9277562

What is rs9277562?

rs9277562 is a single position in the genome, in or near the HLA-DPB1 gene. Published research associates it with chronic hepatitis b infection. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs9277562 linked to?

On MyGeneLog this position is linked to Chronic Hepatitis B. The research behind each link, and its sources, are set out on that condition page.

Does having rs9277562 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs9277562 come from?

GWAS Catalog, Nature genetics 2021, PMID:34594039. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Chronic hepatitis B infection (rs9277562). MyGeneLog™. https://www.mygenelog.com/variants/rs9277562

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