Sensitive
Osteoarthritis of the hip or knee
HLA-DPB1 · rs9277552
Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What each result means
C/C
Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Osteoarthritis of the hip or knee compared to the general population.
C/T
Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Osteoarthritis of the hip or knee.
T/T
Published research associates this genotype with typical/baseline likelihood of Osteoarthritis of the hip or knee — no copies of the reported risk allele.
Source
Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank data
Tachmazidou I,
Hatzikotoulas K,
Southam L,
Esparza-Gordillo J,
Haberland V,
Zheng J,
Johnson T,
Koprulu M,
Zengini E,
Steinberg J,
Wilkinson JM,
Bhatnagar S
and 9 more — show all
Nature genetics · 2019 · PMID 30664745 · open access
Questions about rs9277552
What is rs9277552?
rs9277552 is a single position in the genome, in or near the HLA-DPB1 gene. Published research associates it with osteoarthritis of the hip or knee. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs9277552 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs9277552 come from?
GWAS Catalog, Nat Genet 2019, PMID:30664745. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
← See all variants