HLA-DPB1 · rs9277356
Where this position leads
Condition: Response to Hepatitis B Vaccine
What the study found
Who was studied 1,760 Korean ancestry non-responder adults, 5,107 Korean ancestry responder adults; replicated in 2,327 Korean ancestry adults, 49 Korean ancestry non-responder infants, 234 Korean ancestry responder infants.
The effect Each copy of the A allele carried 1.47 times the odds of Response to hepatitis B vaccine (95% confidence interval 1.38-1.574); p = 7 × 10−31.
How common The A allele had a frequency of about 47% in the people studied.
Where it sits Chromosome 6, band 6p21.32 — a missense change in HLA-DPB1.
rs9277356 is a single position in the genome, in or near the HLA-DPB1 gene. Published research associates it with response to hepatitis b vaccine. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Response to Hepatitis B Vaccine. The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, J Viral Hepat 2019, PMID:31243853. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Response to hepatitis B vaccine (rs9277356). MyGeneLog™. https://www.mygenelog.com/variants/rs9277356