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Sensitive

Parkinson's disease

HLA-DQB · rs9275326

Where this position leads

Condition: Parkinson's Disease

rs9275326 Condition: Parkinson's Disease Parkinson's Disease Condition rs9275326 rs9275326 HLA-DQB

What each result means

C/C Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Parkinson's disease compared to the general population.
C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Parkinson's disease.
T/T Published research associates this genotype with typical/baseline likelihood of Parkinson's disease — no copies of the reported risk allele.
Source
Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease
Nalls MA, Pankratz N, Lill CM, Do CB, Hernandez DG, Saad M, DeStefano AL, Kara E, Bras J, Sharma M, Schulte C, Keller MF
and 35 more — show all
Arepalli S, Letson C, Edsall C, Stefansson H, Liu X, Pliner H, Lee JH, Cheng R, Ikram MA, Ioannidis JP, Hadjigeorgiou GM, Bis JC, Martinez M, Perlmutter JS, Goate A, Marder K, Fiske B, Sutherland M, Xiromerisiou G, Myers RH, Clark LN, Stefansson K, Hardy JA, Heutink P, Chen H, Wood NW, Houlden H, Payami H, Brice A, Scott WK, Gasser T, Bertram L, Eriksson N, Foroud T, Singleton AB
International Parkinson's Disease Genomics Consortium (IPDGC) · Parkinson's Study Group (PSG) Parkinson's Research: The Organized GENetics Initiative (PROGENI) · 23andMe · GenePD · NeuroGenetics Research Consortium (NGRC) · Hussman Institute of Human Genomics (HIHG) · Ashkenazi Jewish Dataset Investigator · Cohorts for Health and Aging Research in Genetic Epidemiology (CHARGE) · North American Brain Expression Consortium (NABEC) · United Kingdom Brain Expression Consortium (UKBEC) · Greek Parkinson's Disease Consortium · Alzheimer Genetic Analysis Group
Nature genetics · 2014 · PMID 25064009 · open access

Questions about rs9275326

What is rs9275326?

rs9275326 is a single position in the genome, in or near the HLA-DQB gene. Published research associates it with parkinson's disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs9275326 linked to?

On MyGeneLog this position is linked to Parkinson's Disease. The research behind each link, and its sources, are set out on that condition page.

Does having rs9275326 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs9275326 come from?

GWAS Catalog, Nat Genet 2014, PMID:25064009. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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