Sensitive

Alzheimer's disease or related dementias

near HLA-DQB1 · rs9275207

Where this position leads

Condition: Alzheimer's Disease

rs9275207 Condition: Alzheimer's Disease Alzheimer's Disease Condition rs9275207 rs9275207 near HLA-DQB1

What the study found

Who was studied 75,638 European ancestry cases, 1,043,805 European ancestry controls.

The effect Each copy of the G allele carried 0.89 times the odds of Alzheimer's disease or related dementias (95% confidence interval 0.87-0.92); p = 2 × 10−19.

How common The G allele had a frequency of about 10% in the people studied.

Where it sits Chromosome 6, band 6p21.32 — between genes, 16.2 kb from MTCO3P1.

What each result means

A/A No copy of the version the research linked to Alzheimer's disease or related dementias. This is the starting point the study compared everyone against.
A/G One copy of the version the research linked to Alzheimer's disease or related dementias. That is a smaller link than two copies.
G/G Two copies of the version the research linked to Alzheimer's disease or related dementias. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs9275207

What is rs9275207?

rs9275207 is a single position in the genome, in or near the near HLA-DQB1 gene. Published research associates it with alzheimer's disease or related dementias. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs9275207 linked to?

On MyGeneLog this position is linked to Alzheimer's Disease. The research behind each link, and its sources, are set out on that condition page.

Does having rs9275207 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs9275207 come from?

GWAS Catalog, Nature genetics 2026, PMID:42237039. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Alzheimer's disease or related dementias (rs9275207). MyGeneLog™. https://www.mygenelog.com/variants/rs9275207

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