Sensitive

Lung cancer in never smokers

near HLA-DQB1 · rs9275164

Where this position leads

Condition: Lung Cancer

rs9275164 Condition: Lung Cancer Lung Cancer Condition rs9275164 rs9275164 near HLA-DQB1

What the study found

Who was studied 8,595 East Asian ancestry female cases, 8,275 East Asian ancestry female controls.

The effect Each copy of the C allele carried 1.20 times the odds of Lung cancer in never smokers (95% confidence interval 1.14-1.26); p = 8 × 10−13.

How common The C allele had a frequency of about 34% in the people studied.

Where it sits Chromosome 6, band 6p21.32 — between genes, 16.8 kb from HLA-DQB1.

What each result means

C/C Two copies of the version the research linked to Lung cancer in never smokers. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/T One copy of the version the research linked to Lung cancer in never smokers. That is a smaller link than two copies.
T/T No copy of the version the research linked to Lung cancer in never smokers. This is the starting point the study compared everyone against.
Source

Questions about rs9275164

What is rs9275164?

rs9275164 is a single position in the genome, in or near the near HLA-DQB1 gene. Published research associates it with lung cancer in never smokers. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs9275164 linked to?

On MyGeneLog this position is linked to Lung Cancer. The research behind each link, and its sources, are set out on that condition page.

Does having rs9275164 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs9275164 come from?

GWAS Catalog, International journal of cancer 2024, PMID:37846649. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Lung cancer in never smokers (rs9275164). MyGeneLog™. https://www.mygenelog.com/variants/rs9275164

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