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Who was studied 11,781 African American or Afro-Caribbean cases, 103,431 African American or Afro-Caribbean controls, 5,658 Hispanic or Latin American cases, 51,648 Hispanic or Latin American controls, 483 East Asian ancestry cases, 6,078 East Asian ancestry controls, 29,668 European ancestry cases, 402,541 European ancestry controls.
The effect
Each copy of the C allele shifted the measure 0.142 lower (95% confidence interval 0.12-0.16); p = 2 × 10−29.
How common The C allele had a frequency of about 89% in the people studied.
Where it sits Chromosome 6, band 6p21.32 — between genes, 3.7 kb from HLA-DQB1.
What each result means
A/ANo copy of the version the research linked to Diabetic retinopathy (PheCode 250.7). This is the starting point the study compared everyone against.
A/COne copy of the version the research linked to Diabetic retinopathy (PheCode 250.7). That is a smaller link than two copies.
C/CTwo copies of the version the research linked to Diabetic retinopathy (PheCode 250.7). That is the strongest link of the three results. A link in a study is not a diagnosis.
Science (New York, N.Y.) · 2024 · PMID 39024449 · open access
Questions about rs9274830
What is rs9274830?
rs9274830 is a single position in the genome, in or near the near HLA-DQB1 gene. Published research associates it with diabetic retinopathy (phecode 250.7). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs9274830 linked to?
On MyGeneLog this position is linked to Diabetic Retinopathy. The research behind each link, and its sources, are set out on that condition page.
Does having rs9274830 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs9274830 come from?
GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
1 1311218Reads by AI crawlersClaude1ChatGPT0Google · Gemini0Perplexity1Meta AI0Microsoft · Copilot0Amazon2Apple1China (ByteDance, Huawei, Baidu…)0Others8Total13Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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