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Diabetic retinopathy

HLA-DQB1 · rs9274619

Where this position leads

Condition: Diabetic Retinopathy

rs9274619 Condition: Diabetic Retinopathy Diabetic Retinopathy Condition rs9274619 rs9274619 HLA-DQB1

What the study found

Who was studied 1,652 European ancestry cases, 60,577 European ancestry controls.

The effect Each copy of the A allele shifted the measure 0.727 higher (95% confidence interval 0.62-0.84); p = 4 × 10−39.

Where it sits Chromosome 6, band 6p21.32 — inside HLA-DQB1.

What each result means

A/A Two copies of the version the research linked to Diabetic retinopathy. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Diabetic retinopathy. That is a smaller link than two copies.
G/G No copy of the version the research linked to Diabetic retinopathy. This is the starting point the study compared everyone against.
Source

Questions about rs9274619

What is rs9274619?

rs9274619 is a single position in the genome, in or near the HLA-DQB1 gene. Published research associates it with diabetic retinopathy. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs9274619 linked to?

On MyGeneLog this position is linked to Diabetic Retinopathy. The research behind each link, and its sources, are set out on that condition page.

Does having rs9274619 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs9274619 come from?

GWAS Catalog, EBioMedicine 2022, PMID:35841873. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Diabetic retinopathy (rs9274619). MyGeneLog™. https://www.mygenelog.com/variants/rs9274619

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