Sensitive

Chronic obstructive pulmonary disease

HLA-DQA1 · rs9272456

Where this position leads

Condition: Chronic Obstructive Pulmonary Disease (COPD)

What the study found

Who was studied 1,503 Admixed American ancestry cases, 13,583 Admixed American ancestry controls, 484 South Asian ancestry cases, 21,464 South Asian ancestry controls, 1,978 African ancestry cases, 27,704 African ancestry controls, 19,044 East Asian ancestry cases, 310,689 East Asian ancestry controls, 58,559 European ancestry cases, 937,358 European ancestry controls; replicated in 1,151 African ancestry cases, 7,542 African ancestry controls, 3,068 European ancestry cases, 43,002 European ancestry controls.

The effect Each copy of the A allele shifted the measure 0.0771 higher (95% confidence interval 0.057-0.097); p = 6 × 10⁻¹⁴.

How common The A allele had a frequency of about 27% in the people studied.

Where it sits Chromosome 6, band 6p21.32 — in an intron of HLA-DQA1.

What each result means

A/A Two copies of the version the research linked to Chronic obstructive pulmonary disease. That is the strongest link of the three results. A link in a study is not a diagnosis.

A/T One copy of the version the research linked to Chronic obstructive pulmonary disease. That is a smaller link than two copies.

T/T No copy of the version the research linked to Chronic obstructive pulmonary disease. This is the starting point the study compared everyone against.

Source

Global Biobank Meta-analysis Initiative: Powering genetic discovery across human disease

Zhou W, Kanai M, Wu KH, Rasheed H, Tsuo K, Hirbo JB, Wang Y, Bhattacharya A, Zhao H, Namba S, Surakka I, Wolford BN

and 140 more — show all

Lo Faro V, Lopera-Maya EA, Läll K, Favé MJ, Partanen JJ, Chapman SB, Karjalainen J, Kurki M, Maasha M, Brumpton BM, Chavan S, Chen TT, Daya M, Ding Y, Feng YA, Guare LA, Gignoux CR, Graham SE, Hornsby WE, Ingold N, Ismail SI, Johnson R, Laisk T, Lin K, Lv J, Millwood IY, Moreno-Grau S, Nam K, Palta P, Pandit A, Preuss MH, Saad C, Setia-Verma S, Thorsteinsdottir U, Uzunovic J, Verma A, Zawistowski M, Zhong X, Afifi N, Al-Dabhani KM, Al Thani A, Bradford Y, Campbell A, Crooks K, de Bock GH, Damrauer SM, Douville NJ, Finer S, Fritsche LG, Fthenou E, Gonzalez-Arroyo G, Griffiths CJ, Guo Y, Hunt KA, Ioannidis A, Jansonius NM, Konuma T, Lee MTM, Lopez-Pineda A, Matsuda Y, Marioni RE, Moatamed B, Nava-Aguilar MA, Numakura K, Patil S, Rafaels N, Richmond A, Rojas-Muñoz A, Shortt JA, Straub P, Tao R, Vanderwerff B, Vernekar M, Veturi Y, Barnes KC, Boezen M, Chen Z, Chen CY, Cho J, Smith GD, Finucane HK, Franke L, Gamazon ER, Ganna A, Gaunt TR, Ge T, Huang H, Huffman J, Katsanis N, Koskela JT, Lajonchere C, Law MH, Li L, Lindgren CM, Loos RJF, MacGregor S, Matsuda K, Olsen CM, Porteous DJ, Shavit JA, Snieder H, Takano T, Trembath RC, Vonk JM, Whiteman DC, Wicks SJ, Wijmenga C, Wright J, Zheng J, Zhou X, Awadalla P, Boehnke M, Bustamante CD, Cox NJ, Fatumo S, Geschwind DH, Hayward C, Hveem K, Kenny EE, Lee S, Lin YF, Mbarek H, Mägi R, Martin HC, Medland SE, Okada Y, Palotie AV, Pasaniuc B, Rader DJ, Ritchie MD, Sanna S, Smoller JW, Stefansson K, van Heel DA, Walters RG, Zöllner S, Martin AR, Willer CJ, Daly MJ, Neale BM

Cell genomics · 2022 · PMID 36777996 · open access

Questions about rs9272456

What is rs9272456?

rs9272456 is a single position in the genome, in or near the HLA-DQA1 gene. Published research associates it with chronic obstructive pulmonary disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs9272456 linked to?

On MyGeneLog this position is linked to Chronic Obstructive Pulmonary Disease (COPD). The research behind each link, and its sources, are set out on that condition page.

Does having rs9272456 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs9272456 come from?

GWAS Catalog, Cell genomics 2022, PMID:36777996. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Chronic obstructive pulmonary disease (rs9272456). MyGeneLog™. https://www.mygenelog.com/variants/rs9272456

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