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Waist-to-hip ratio adjusted for BMI

HLA-DQA1 · rs9271880

What the study found

Who was studied 219,872 British ancestry women.

The effect Each copy of the C allele shifted the measure 0.0194 lower (95% confidence interval 0.013-0.025); p = 2 × 10−10.

Where it sits Chromosome 6, band 6p21.32 — between genes, 0.4 kb from HLA-DQA1.

What each result means

C/C Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Waist-to-hip ratio adjusted for BMI compared to the general population.
C/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Waist-to-hip ratio adjusted for BMI.
G/G Published research associates this genotype with typical/baseline likelihood of Waist-to-hip ratio adjusted for BMI — no copies of the reported risk allele.
Source

Questions about rs9271880

What is rs9271880?

rs9271880 is a single position in the genome, in or near the HLA-DQA1 gene. Published research associates it with waist-to-hip ratio adjusted for bmi. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs9271880 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs9271880 come from?

GWAS Catalog, Scientific reports 2021, PMID:34021172. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Waist-to-hip ratio adjusted for BMI (rs9271880). MyGeneLog™. https://www.mygenelog.com/variants/rs9271880

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