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COVID-19 (critical illness vs population or mild symptoms)

near HLA-DQA1 · rs9271609

What the study found

Who was studied 5,989 European ancestry cases, 42,891 European ancestry controls.

The effect Each copy of the T allele carried 1.10 times the odds of COVID-19 (critical illness vs population or mild symptoms) (95% confidence interval 1.09-1.19); p = 3 × 10−9.

How common The T allele had a frequency of about 65% in the people studied.

Where it sits Chromosome 6, band 6p21.32 — between genes, 4.4 kb from HLA-DQA1.

What each result means

C/C No copy of the version the research linked to COVID-19 (critical illness vs population or mild symptoms). This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to COVID-19 (critical illness vs population or mild symptoms). That is a smaller link than two copies.
T/T Two copies of the version the research linked to COVID-19 (critical illness vs population or mild symptoms). That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs9271609

What is rs9271609?

rs9271609 is a single position in the genome, in or near the near HLA-DQA1 gene. Published research associates it with covid-19 (critical illness vs population or mild symptoms). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs9271609 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs9271609 come from?

GWAS Catalog, Nature 2022, PMID:35255492. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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COVID-19 (critical illness vs population or mild symptoms) (rs9271609). MyGeneLog™. https://www.mygenelog.com/variants/rs9271609

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