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Chronic lymphocytic leukemia

HLA-DQB1 · rs9270750

Where this position leads

Condition: Chronic Lymphocytic Leukaemia

What the study found

Who was studied 3,100 European ancestry cases, 7,667 European ancestry controls; replicated in 1,958 cases, 5,530 controls.

The effect Each copy of the A allele carried 1.32 times the odds of Chronic lymphocytic leukemia (95% confidence interval 1.23-1.41); p = 6 × 10⁻¹⁶.

How common The A allele had a frequency of about 54% in the people studied.

Where it sits Chromosome 6, band 6p21.32 — between genes, 10.7 kb from HLA-DRB1.

What each result means

A/A Two copies of the version the research linked to Chronic lymphocytic leukemia. That is the strongest link of the three results. A link in a study is not a diagnosis.

A/G One copy of the version the research linked to Chronic lymphocytic leukemia. That is a smaller link than two copies.

G/G No copy of the version the research linked to Chronic lymphocytic leukemia. This is the starting point the study compared everyone against.

Source

Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia

Berndt SI, Camp NJ, Skibola CF, Vijai J, Wang Z, Gu J, Nieters A, Kelly RS, Smedby KE, Monnereau A, Cozen W, Cox A

and 115 more — show all

Wang SS, Lan Q, Teras LR, Machado M, Yeager M, Brooks-Wilson AR, Hartge P, Purdue MP, Birmann BM, Vajdic CM, Cocco P, Zhang Y, Giles GG, Zeleniuch-Jacquotte A, Lawrence C, Montalvan R, Burdett L, Hutchinson A, Ye Y, Call TG, Shanafelt TD, Novak AJ, Kay NE, Liebow M, Cunningham JM, Allmer C, Hjalgrim H, Adami HO, Melbye M, Glimelius B, Chang ET, Glenn M, Curtin K, Cannon-Albright LA, Diver WR, Link BK, Weiner GJ, Conde L, Bracci PM, Riby J, Arnett DK, Zhi D, Leach JM, Holly EA, Jackson RD, Tinker LF, Benavente Y, Sala N, Casabonne D, Becker N, Boffetta P, Brennan P, Foretova L, Maynadie M, McKay J, Staines A, Chaffee KG, Achenbach SJ, Vachon CM, Goldin LR, Strom SS, Leis JF, Weinberg JB, Caporaso NE, Norman AD, De Roos AJ, Morton LM, Severson RK, Riboli E, Vineis P, Kaaks R, Masala G, Weiderpass E, Chirlaque MD, Vermeulen RCH, Travis RC, Southey MC, Milne RL, Albanes D, Virtamo J, Weinstein S, Clavel J, Zheng T, Holford TR, Villano DJ, Maria A, Spinelli JJ, Gascoyne RD, Connors JM, Bertrand KA, Giovannucci E, Kraft P, Kricker A, Turner J, Ennas MG, Ferri GM, Miligi L, Liang L, Ma B, Huang J, Huang J, Crouch S, Park JH, Chatterjee N, North KE, Snowden JA, Wright J, Fraumeni JF, Offit K, Wu X, de Sanjose S, Cerhan JR, Chanock SJ, Rothman N, Slager SL

Nature communications · 2016 · PMID 26956414 · open access

Questions about rs9270750

What is rs9270750?

rs9270750 is a single position in the genome, in or near the HLA-DQB1 gene. Published research associates it with chronic lymphocytic leukemia. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs9270750 linked to?

On MyGeneLog this position is linked to Chronic Lymphocytic Leukaemia. The research behind each link, and its sources, are set out on that condition page.

Does having rs9270750 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs9270750 come from?

GWAS Catalog, Nature communications 2016, PMID:26956414. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Chronic lymphocytic leukemia (rs9270750). MyGeneLog™. https://www.mygenelog.com/variants/rs9270750

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