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Reticulocyte count

HLA-DRB1 · rs9270493

Where this position leads

Condition: Blood Cell Counts

rs9270493 Condition: Blood Cell Counts Blood Cell Counts Condition rs9270493 rs9270493 HLA-DRB1

What the study found

Who was studied 170,641 European ancestry individuals.

The effect Each copy of the C allele shifted the measure 0.0615 lower (95% confidence interval 0.053-0.07); p = 1 × 10−46.

How common The C allele had a frequency of about 23% in the people studied.

Where it sits Chromosome 6, band 6p21.32 — between genes, 1.5 kb from HLA-DRB1.

What each result means

C/C Two copies of the version the research linked to Reticulocyte count. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/T One copy of the version the research linked to Reticulocyte count. That is a smaller link than two copies.
T/T No copy of the version the research linked to Reticulocyte count. This is the starting point the study compared everyone against.
Source

Questions about rs9270493

What is rs9270493?

rs9270493 is a single position in the genome, in or near the HLA-DRB1 gene. Published research associates it with reticulocyte count. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs9270493 linked to?

On MyGeneLog this position is linked to Blood Cell Counts. The research behind each link, and its sources, are set out on that condition page.

Does having rs9270493 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs9270493 come from?

GWAS Catalog, Cell 2016, PMID:27863252. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Reticulocyte count (rs9270493). MyGeneLog™. https://www.mygenelog.com/variants/rs9270493

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