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Who was studied schizophrenia cases and controls (see Ripke, 2014), up to 6,197 European ancestry ASD cases, up to 7,377 European ancestry controls, up to 1,190 ASD cases, up to 1,190 controls.
The effect
Each copy of the T allele carried 1.11 times the odds of Autism spectrum disorder or schizophrenia (95% confidence interval 1.08-1.14); p = 4 × 10−15.
Where it sits Chromosome 6, band 6p21.32 — between genes, 6.6 kb from HLA-DRB1.
What each result means
C/CNo copy of the version the research linked to Autism spectrum disorder or schizophrenia. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Autism spectrum disorder or schizophrenia. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Autism spectrum disorder or schizophrenia. That is the strongest link of the three results. A link in a study is not a diagnosis.
Molecular autism · 2017 · PMID 28540026 · open access
Questions about rs9269271
What is rs9269271?
rs9269271 is a single position in the genome, in or near the HLA-DRA gene. Published research associates it with autism spectrum disorder or schizophrenia. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs9269271 linked to?
On MyGeneLog this position is linked to Schizophrenia. The research behind each link, and its sources, are set out on that condition page.
Does having rs9269271 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs9269271 come from?
GWAS Catalog, Molecular autism 2017, PMID:28540026. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Autism spectrum disorder or schizophrenia (rs9269271). MyGeneLog™. https://www.mygenelog.com/variants/rs9269271