Sensitive

Type 1 diabetes

near HLA-DRB9 · rs9269173

Where this position leads

Condition: Type 1 Diabetes

rs9269173 Condition: Type 1 Diabetes Type 1 Diabetes Condition rs9269173 rs9269173 near HLA-DRB9

What the study found

Who was studied 1,275 Han Chinese ancestry cases, 2,100 Han Chinese ancestry controls; replicated in up to 1,720 East Asian ancestry cases, up to 132,885 East Asian ancestry controls.

The effect Each copy of the T allele carried 5.54 times the odds of Type 1 diabetes (95% confidence interval 5.29-5.8); p = 4 × 10−42.

How common The T allele had a frequency of about 4% in the people studied.

Where it sits Chromosome 6, band 6p21.32 — between genes, 5.9 kb from HLA-DRB9.

What each result means

A/A No copy of the version the research linked to Type 1 diabetes. This is the starting point the study compared everyone against.
A/T One copy of the version the research linked to Type 1 diabetes. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Type 1 diabetes. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs9269173

What is rs9269173?

rs9269173 is a single position in the genome, in or near the near HLA-DRB9 gene. Published research associates it with type 1 diabetes. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs9269173 linked to?

On MyGeneLog this position is linked to Type 1 Diabetes. The research behind each link, and its sources, are set out on that condition page.

Does having rs9269173 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs9269173 come from?

GWAS Catalog, Diabetologia 2025, PMID:40569436. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Type 1 diabetes (rs9269173). MyGeneLog™. https://www.mygenelog.com/variants/rs9269173

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