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Primary biliary cholangitis

near HLA-DRA · rs9268641

Where this position leads

Condition: Primary Biliary Cholangitis

rs9268641 Condition: Primary Biliary Cholangitis Primary Biliary Cholangitis Condition rs9268641 rs9268641 near HLA-DRA

What each result means

C/C Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Primary biliary cholangitis compared to the general population.
C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Primary biliary cholangitis.
T/T Published research associates this genotype with typical/baseline likelihood of Primary biliary cholangitis — no copies of the reported risk allele.
Source
A genome-wide association study identified PTPN2 as a population-specific susceptibility gene locus for primary biliary cholangitis
Hitomi Y, Ueno K, Aiba Y, Nishida N, Kono M, Sugihara M, Kawai Y, Kawashima M, Khor SS, Sugi K, Kouno H, Kohno H
and 52 more — show all
Naganuma A, Iwamoto S, Katsushima S, Furuta K, Nikami T, Mannami T, Yamashita T, Ario K, Komatsu T, Makita F, Shimada M, Hirashima N, Yokohama S, Nishimura H, Sugimoto R, Komura T, Ota H, Kojima M, Nakamuta M, Fujimori N, Yoshizawa K, Mano Y, Takahashi H, Hirooka K, Tsuruta S, Sato T, Yamasaki K, Kugiyama Y, Motoyoshi Y, Suehiro T, Saeki A, Matsumoto K, Nagaoka S, Abiru S, Yatsuhashi H, Ito M, Kawata K, Takaki A, Arai K, Arinaga-Hino T, Abe M, Harada M, Taniai M, Zeniya M, Ohira H, Shimoda S, Komori A, Tanaka A, Ishigaki K, Nagasaki M, Tokunaga K, Nakamura M
Hepatology (Baltimore, Md.) · 2024 · PMID 38652555

Questions about rs9268641

What is rs9268641?

rs9268641 is a single position in the genome, in or near the near HLA-DRA gene. Published research associates it with primary biliary cholangitis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs9268641 linked to?

On MyGeneLog this position is linked to Primary Biliary Cholangitis. The research behind each link, and its sources, are set out on that condition page.

Does having rs9268641 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs9268641 come from?

GWAS Catalog, Hepatology (Baltimore, Md.) 2024, PMID:38652555. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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