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Human papilloma virus 16 positive oropharyngeal cancer

HLA-B · rs9266329

Where this position leads

Drugs: Abacavir, Allopurinol, Carbamazepine and oxcarbazepine

rs9266329 Drug: Abacavir Abacavir Drug Drug: Allopurinol Allopurinol Drug Drug: Carbamazepine and oxcarbazepine Carbamazepine and oxcarbazepine Drug rs9266329 rs9266329 HLA-B

What the study found

Who was studied 1,078 European ancestry cases, 5,256 European ancestry controls.

The effect The reported allele is A; the catalogue records no effect size ; p = 1 × 10−12.

Where it sits Chromosome 6, band 6p21.33 — in a non-coding transcript of HLA-B.

What each result means

A/A Two copies of the version the research linked to Human papilloma virus 16 positive oropharyngeal cancer. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Human papilloma virus 16 positive oropharyngeal cancer. That is a smaller link than two copies.
G/G No copy of the version the research linked to Human papilloma virus 16 positive oropharyngeal cancer. This is the starting point the study compared everyone against.
Source
Germline determinants of humoral immune response to HPV-16 protect against oropharyngeal cancer
Ferreiro-Iglesias A, McKay JD, Brenner N, Virani S, Lesseur C, Gaborieau V, Ness AR, Hung RJ, Liu G, Diergaarde B, Olshan AF, Hayes N
and 40 more — show all
Weissler MC, Schroeder L, Bender N, Pawlita M, Thomas S, Pring M, Dudding T, Kanterewicz B, Ferris R, Thomas S, Brhane Y, Díez-Obrero V, Milojevic M, Smith-Byrne K, Mariosa D, Johansson MJ, Herrero R, Boccia S, Cadoni G, Lacko M, Holcátová I, Ahrens W, Lagiou P, Lagiou A, Polesel J, Simonato L, Merletti F, Healy CM, Hansen BT, Nygård M, Conway DI, Wright S, Macfarlane TV, Robinson M, Alemany L, Agudo A, Znaor A, Amos CI, Waterboer T, Brennan P
Nature communications · 2021 · PMID 34642315 · open access

Questions about rs9266329

What is rs9266329?

rs9266329 is a single position in the genome, in or near the HLA-B gene. Published research associates it with human papilloma virus 16 positive oropharyngeal cancer. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does rs9266329 affect how medicines work?

HLA-B carries pharmacogenomic findings for Abacavir, Allopurinol, Carbamazepine and oxcarbazepine. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.

Does having rs9266329 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs9266329 come from?

GWAS Catalog, Nature communications 2021, PMID:34642315. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Human papilloma virus 16 positive oropharyngeal cancer (rs9266329). MyGeneLog™. https://www.mygenelog.com/variants/rs9266329

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