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Who was studied 1,873 European ancestry cases, 36,370 European ancestry controls; replicated in 7,412 European ancestry individuals.
The effect
Each copy of the A allele carried 1.29 times the odds of Myasthenia gravis (95% confidence interval 1.2-1.4); p = 7 × 10−10.
How common The A allele had a frequency of about 35% in the people studied.
Where it sits Chromosome 6, band 6p21.33 — in an intron of HLA-B.
What each result means
A/ATwo copies of the version the research linked to Myasthenia gravis. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Myasthenia gravis. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Myasthenia gravis. This is the starting point the study compared everyone against.
Proceedings of the National Academy of Sciences of the United States of America · 2022 · PMID 35074870 · open access
Questions about rs9266277
What is rs9266277?
rs9266277 is a single position in the genome, in or near the HLA-B gene. Published research associates it with myasthenia gravis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs9266277 linked to?
On MyGeneLog this position is linked to Myasthenia Gravis. The research behind each link, and its sources, are set out on that condition page.
Does rs9266277 affect how medicines work?
HLA-B carries pharmacogenomic findings for Abacavir, Allopurinol, Carbamazepine and oxcarbazepine. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.
Does having rs9266277 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs9266277 come from?
GWAS Catalog, Proceedings of the National Academy of Sciences of the United States of America 2022, PMID:35074870. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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