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Chickenpox

HLA-B · rs9266089

Where this position leads

Condition: Tonsillectomy (Throat Infection Susceptibility)

Drugs: Abacavir, Allopurinol, Carbamazepine and oxcarbazepine

rs9266089 Condition: Tonsillectomy (Throat Infection Susceptibility) Tonsillectomy (Throat Infection Sus… Condition Drug: Abacavir Abacavir Drug Drug: Allopurinol Allopurinol Drug Drug: Carbamazepine and oxcarbazepine Carbamazepine and oxcarbazepine Drug rs9266089 rs9266089 HLA-B

What the study found

Who was studied 107,769 European ancestry cases, 15,982 European ancestry controls.

The effect Each copy of the G allele carried 1.12 times the odds of Chickenpox (95% confidence interval 1.1-1.14); p = 1 × 10−10.

How common The G allele had a frequency of about 85% in the people studied.

Where it sits Chromosome 6, band 6p21.33 — between genes, 1.1 kb from HLA-B.

What each result means

A/A Published research associates this genotype with typical/baseline likelihood of Chickenpox — no copies of the reported risk allele.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Chickenpox.
G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Chickenpox compared to the general population.
Source
Genome-wide association and HLA region fine-mapping studies identify susceptibility loci for multiple common infections
Tian C, Hromatka BS, Kiefer AK, Eriksson N, Noble SM, Tung JY, Hinds DA
Nature communications · 2017 · PMID 28928442 · open access

Questions about rs9266089

What is rs9266089?

rs9266089 is a single position in the genome, in or near the HLA-B gene. Published research associates it with chickenpox. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs9266089 linked to?

On MyGeneLog this position is linked to Tonsillectomy (Throat Infection Susceptibility). The research behind each link, and its sources, are set out on that condition page.

Does rs9266089 affect how medicines work?

HLA-B carries pharmacogenomic findings for Abacavir, Allopurinol, Carbamazepine and oxcarbazepine. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.

Does having rs9266089 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs9266089 come from?

GWAS Catalog, Nat Commun 2017, PMID:28928442. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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