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Graves' disease

near HLA-B · rs9265428

Where this position leads

Condition: Graves' Disease

rs9265428 Condition: Graves' Disease Graves' Disease Condition rs9265428 rs9265428 near HLA-B

What the study found

Who was studied 18,719 African ancestry, admixed American, East Asian ancestry, European ancestry, South Asian ancestry, Greater Middle Eastern cases, 2,441,938 African ancestry, admixed American, East Asian ancestry, European ancestry, South Asian ancestry, Greater Middle Eastern controls.

The effect Each copy of the T allele shifted the measure 0.146 higher (95% confidence interval 0.12-0.17); p = 3 × 10−24.

How common The T allele had a frequency of about 65% in the people studied.

Where it sits Chromosome 6, band 6p21.33 — between genes, 25.5 kb from HLA-B.

What each result means

C/C No copy of the version the research linked to Graves' disease. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Graves' disease. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Graves' disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source
Global multi-ancestry genome-wide analyses identify genes and biological pathways associated with thyroid cancer and benign thyroid diseases
White SL, Brasher MS, Pattee J, Zhou W, Chapman S, Jee YH, Bell CC, Jamil TL, Barrio M, Arehart CH, Evans LM, Hirbo J
and 73 more — show all
Cox NJ, Straub P, Namba S, Bertucci-Richter E, Guare L, Edris A, Morris S, Mulford AJ, Zhang H, Fennessy B, Tobin MD, Chen J, Williams AT, John C, van Heel DA, Mathur R, Finer S, Moksnes MR, Brumpton BM, Åsvold BO, Peculis R, Rovite V, Konrade I, Wang Y, Crooks K, Chavan S, Fisher MJ, Rafaels N, Lin M, Shortt JA, Sanders AR, Whiteman DC, MacGregor S, Medland SE, Thorsteinsdóttir U, Stefánsson K, Karaderi T, Egan KM, Bocklage T, McCrary HC, Riedlinger G, Salhia B, Shriver C, Phan MD, Farlow JL, Edge S, Kaur V, Churchman ML, Rounbehler RJ, Brock PL, Ringel MD, Pividori M, Schweppe R, Raeburn CD, Walters RG, Chen Z, Li L, Matsuda K, Okada Y, Zöllner S, Verma A, Preuss MH, Kenny E, Hendricks AE, Fishbein L, Kraft P, Daly MJ, Neale BM, Martin AR, Cole JB, Haugen BR, Gignoux CR, Pozdeyev N
Penn Medicine BioBank · Virtual Thyroid Biopsy Consortium · Colorado Center for Personalized Medicine · Genes & Health Research Team · BioBank Japan Project · Global Biobank Meta-analysis Initiative
Nature genetics · 2026 · PMID 41644669 · open access

Questions about rs9265428

What is rs9265428?

rs9265428 is a single position in the genome, in or near the near HLA-B gene. Published research associates it with graves' disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs9265428 linked to?

On MyGeneLog this position is linked to Graves' Disease. The research behind each link, and its sources, are set out on that condition page.

Does having rs9265428 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs9265428 come from?

GWAS Catalog, Nature genetics 2026, PMID:41644669. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Graves' disease (rs9265428). MyGeneLog™. https://www.mygenelog.com/variants/rs9265428

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