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Ulcerative colitis

HLA · rs9263739

Where this position leads

Condition: Ulcerative Colitis

rs9263739 Condition: Ulcerative Colitis Ulcerative Colitis Condition rs9263739 rs9263739 HLA

What the study found

Who was studied 376 Japanese ancestry cases, 934 Japanese ancestry controls; replicated in 376 Japanese ancestry cases, 1,097 Japanese ancestry controls.

The effect Each copy of the T allele carried 2.73 times the odds of Ulcerative colitis (95% confidence interval 2.43-3.07); p = 4 × 10−67.

How common The T allele had a frequency of about 15% in the people studied.

Where it sits Chromosome 6, band 6p21.33 — in an intron of CCHCR1.

What each result means

C/C No copy of the version the research linked to Ulcerative colitis. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Ulcerative colitis. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Ulcerative colitis. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs9263739

What is rs9263739?

rs9263739 is a single position in the genome, in or near the HLA gene. Published research associates it with ulcerative colitis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs9263739 linked to?

On MyGeneLog this position is linked to Ulcerative Colitis. The research behind each link, and its sources, are set out on that condition page.

Does having rs9263739 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs9263739 come from?

GWAS Catalog, Nat Genet 2009, PMID:19915573. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Ulcerative colitis (rs9263739). MyGeneLog™. https://www.mygenelog.com/variants/rs9263739

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