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Malignant lymphoma (Non-Hodgkin lymphoma, multiple myeloma, or Hodgkin lymphoma)

POLR1HASP · rs9258807

Where this position leads

What the study found

Who was studied 13,763 European ancestry cases, 18,862 European ancestry controls.

The effect Each copy of the C allele carried 0.85 times the odds of Malignant lymphoma (Non-Hodgkin lymphoma, multiple myeloma, or Hodgkin lymphoma) (95% confidence interval 0.81-0.89); p = 1 × 10⁻¹⁰.

Where it sits Chromosome 6, band 6p22.1 — in an intron of POLR1HASP.

What each result means

C/C Two copies of the version the research linked to Malignant lymphoma (Non-Hodgkin lymphoma, multiple myeloma, or Hodgkin lymphoma). That is the strongest link of the three results. A link in a study is not a diagnosis.

C/T One copy of the version the research linked to Malignant lymphoma (Non-Hodgkin lymphoma, multiple myeloma, or Hodgkin lymphoma). That is a smaller link than two copies.

T/T No copy of the version the research linked to Malignant lymphoma (Non-Hodgkin lymphoma, multiple myeloma, or Hodgkin lymphoma). This is the starting point the study compared everyone against.

Source

Distinct germline genetic susceptibility profiles identified for common non-Hodgkin lymphoma subtypes

Berndt SI, Vijai J, Benavente Y, Camp NJ, Nieters A, Wang Z, Smedby KE, Kleinstern G, Hjalgrim H, Besson C, Skibola CF, Morton LM

and 128 more — show all

Brooks-Wilson AR, Teras LR, Breeze C, Arias J, Adami HO, Albanes D, Anderson KC, Ansell SM, Bassig B, Becker N, Bhatti P, Birmann BM, Boffetta P, Bracci PM, Brennan P, Brown EE, Burdett L, Cannon-Albright LA, Chang ET, Chiu BCH, Chung CC, Clavel J, Cocco P, Colditz G, Conde L, Conti DV, Cox DG, Curtin K, Casabonne D, De Vivo I, Diepstra A, Diver WR, Dogan A, Edlund CK, Foretova L, Fraumeni JF Jr, Gabbas A, Ghesquières H, Giles GG, Glaser S, Glenn M, Glimelius B, Gu J, Habermann TM, Haiman CA, Haioun C, Hofmann JN, Holford TR, Holly EA, Hutchinson A, Izhar A, Jackson RD, Jarrett RF, Kaaks R, Kane E, Kolonel LN, Kong Y, Kraft P, Kricker A, Lake A, Lan Q, Lawrence C, Li D, Liebow M, Link BK, Magnani C, Maynadie M, McKay J, Melbye M, Miligi L, Milne RL, Molina TJ, Monnereau A, Montalvan R, North KE, Novak AJ, Onel K, Purdue MP, Rand KA, Riboli E, Riby J, Roman E, Salles G, Sborov DW, Severson RK, Shanafelt TD, Smith MT, Smith A, Song KW, Song L, Southey MC, Spinelli JJ, Staines A, Stephens D, Sutherland HJ, Tkachuk K, Thompson CA, Tilly H, Tinker LF, Travis RC, Turner J, Vachon CM, Vajdic CM, Van Den Berg A, Van Den Berg DJ, Vermeulen RCH, Vineis P, Wang SS, Weiderpass E, Weiner GJ, Weinstein S, Doo NW, Ye Y, Yeager M, Yu K, Zeleniuch-Jacquotte A, Zhang Y, Zheng T, Ziv E, Sampson J, Chatterjee N, Offit K, Cozen W, Wu X, Cerhan JR, Chanock SJ, Slager SL, Rothman N

Leukemia · 2022 · PMID 36273105

Questions about rs9258807

What is rs9258807?

rs9258807 is a single position in the genome, in or near the POLR1HASP gene. Published research associates it with malignant lymphoma (non-hodgkin lymphoma, multiple myeloma, or hodgkin lymphoma). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs9258807 linked to?

On MyGeneLog this position is linked to Hodgkin Lymphoma. The research behind each link, and its sources, are set out on that condition page.

Does having rs9258807 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs9258807 come from?

GWAS Catalog, Leukemia 2022, PMID:36273105. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Malignant lymphoma (Non-Hodgkin lymphoma, multiple myeloma, or Hodgkin lymphoma) (rs9258807). MyGeneLog™. https://www.mygenelog.com/variants/rs9258807

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