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Lung cancer or family history of lung cancer

HLA-F-AS1 · rs9258381

Where this position leads

Condition: Lung Cancer

rs9258381 Condition: Lung Cancer Lung Cancer Condition rs9258381 rs9258381 HLA-F-AS1

What the study found

Who was studied 29,266 European ancestry lung cancer cases, 48,843 European ancestry individuals with family history of lung cancer, 251,837 European ancestry controls.

The effect Each copy of the A allele carried 1.11 times the odds of Lung cancer or family history of lung cancer (95% confidence interval 1.09-1.135); p = 3 × 10−20.

How common The A allele had a frequency of about 14% in the people studied.

Where it sits Chromosome 6, band 6p22.1 — in an intron of HLA-F-AS1.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Lung cancer or family history of lung cancer compared to the general population.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Lung cancer or family history of lung cancer.
G/G Published research associates this genotype with typical/baseline likelihood of Lung cancer or family history of lung cancer — no copies of the reported risk allele.
Source
Genetic Analysis of Lung Cancer and the Germline Impact on Somatic Mutation Burden
Gabriel AAG, Atkins JR, Penha RCC, Smith-Byrne K, Gaborieau V, Voegele C, Abedi-Ardekani B, Milojevic M, Olaso R, Meyer V, Boland A, Deleuze JF
and 21 more — show all
Zaridze D, Mukeriya A, Swiatkowska B, Janout V, Schejbalová M, Mates D, Stojšić J, Ognjanovic M, Witte JS, Rashkin SR, Kachuri L, Hung RJ, Kar S, Brennan P, Sertier AS, Ferrari A, Viari A, Johansson M, Amos CI, Foll M, McKay JD
ILCCO consortium
Journal of the National Cancer Institute · 2022 · PMID 35511172 · open access

Questions about rs9258381

What is rs9258381?

rs9258381 is a single position in the genome, in or near the HLA-F-AS1 gene. Published research associates it with lung cancer or family history of lung cancer. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs9258381 linked to?

On MyGeneLog this position is linked to Lung Cancer. The research behind each link, and its sources, are set out on that condition page.

Does having rs9258381 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs9258381 come from?

GWAS Catalog, Journal of the National Cancer Institute 2022, PMID:35511172. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Lung cancer or family history of lung cancer (rs9258381). MyGeneLog™. https://www.mygenelog.com/variants/rs9258381

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