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Thyroid stimulating hormone levels

PTCSC2 · rs925488

Where this position leads

Condition: Thyroid Stimulating Hormone (TSH) Levels

rs925488 Condition: Thyroid Stimulating Hormone (TSH) Levels Thyroid Stimulating Hormone (TSH) Levels Condition rs925488 rs925488 PTCSC2

What the study found

Who was studied 119,715 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.0583 SD higher (95% confidence interval 0.049-0.068); p = 5 × 10−34.

How common The A allele had a frequency of about 66% in the people studied.

Where it sits Chromosome 9, band 9q22.33 — in an intron of PTCSC2.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Thyroid stimulating hormone levels compared to the general population.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Thyroid stimulating hormone levels.
G/G Published research associates this genotype with typical/baseline likelihood of Thyroid stimulating hormone levels — no copies of the reported risk allele.
Source
GWAS of thyroid stimulating hormone highlights pleiotropic effects and inverse association with thyroid cancer
Zhou W, Brumpton B, Kabil O, Gudmundsson J, Thorleifsson G, Weinstock J, Zawistowski M, Nielsen JB, Chaker L, Medici M, Teumer A, Naitza S
and 44 more — show all
Sanna S, Schultheiss UT, Cappola A, Karjalainen J, Kurki M, Oneka M, Taylor P, Fritsche LG, Graham SE, Wolford BN, Overton W, Rasheed H, Haug EB, Gabrielsen ME, Skogholt AH, Surakka I, Davey Smith G, Pandit A, Roychowdhury T, Hornsby WE, Jonasson JG, Senter L, Liyanarachchi S, Ringel MD, Xu L, Kiemeney LA, He H, Netea-Maier RT, Mayordomo JI, Plantinga TS, Hrafnkelsson J, Hjartarson H, Sturgis EM, Palotie A, Daly M, Citterio CE, Arvan P, Brummett CM, Boehnke M, de la Chapelle A, Stefansson K, Hveem K, Willer CJ, Åsvold BO
Nature communications · 2020 · PMID 32769997 · open access

Questions about rs925488

What is rs925488?

rs925488 is a single position in the genome, in or near the PTCSC2 gene. Published research associates it with thyroid stimulating hormone levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs925488 linked to?

On MyGeneLog this position is linked to Thyroid Stimulating Hormone (TSH) Levels. The research behind each link, and its sources, are set out on that condition page.

Does having rs925488 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs925488 come from?

GWAS Catalog, Nat Commun 2020, PMID:32769997. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Thyroid stimulating hormone levels (rs925488). MyGeneLog™. https://www.mygenelog.com/variants/rs925488

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