Sensitive

Hepatocellular carcinoma

near EPHA2-AS1 · rs924204

Where this position leads

Condition: HBV-Related Hepatocellular Carcinoma

What the study found

Who was studied 977 African ancestry cases, 120,676 African ancestry controls, 630 Hispanic or Latin American cases, 59,146 Hispanic or Latin American controls, 7,355 East Asian ancestry cases, 629,454 East Asian ancestry controls, 8,216 European ancestry cases, 1,558,609 European ancestry controls, 519 cases, 347,798 controls.

The effect Each copy of the G allele shifted the measure 0.006 higher (95% confidence interval 0.0042-0.0078); p = 7 × 10⁻¹³.

How common The G allele had a frequency of about 65% in the people studied.

Where it sits Chromosome 1, band 1p36.13 — between genes, 4.3 kb from EPHA2-AS1.

What each result means

A/A Published research associates this genotype with typical/baseline likelihood of Hepatocellular carcinoma — no copies of the reported risk allele.

A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Hepatocellular carcinoma.

G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Hepatocellular carcinoma compared to the general population.

Source

Multi-ancestry genome-wide association meta-analysis of hepatocellular carcinoma identifies 15 risk loci including MAP3K9, DHRS1, MTTP, and 8q24.21

Chinaka I, Schofield A, Amos CI, Roberts LR, Chen VL, Han Y, Hassan M, Shetty S, Mann JP

HGG advances · 2026 · PMID 42357869 · open access

Questions about rs924204

What is rs924204?

rs924204 is a single position in the genome, in or near the near EPHA2-AS1 gene. Published research associates it with hepatocellular carcinoma. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs924204 linked to?

On MyGeneLog this position is linked to HBV-Related Hepatocellular Carcinoma. The research behind each link, and its sources, are set out on that condition page.

Does having rs924204 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs924204 come from?

GWAS Catalog, HGG advances 2026, PMID:42357869. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Hepatocellular carcinoma (rs924204). MyGeneLog™. https://www.mygenelog.com/variants/rs924204

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