Standard

Platelet count

SIGLEC11 · rs919777

Where this position leads

Condition: Blood Cell Counts

rs919777 Condition: Blood Cell Counts Blood Cell Counts Condition rs919777 rs919777 SIGLEC11

What the study found

Who was studied 507,850 East Asian ancestry individuals, 420,829 European ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.0293 lower (95% confidence interval 0.025-0.034); p = 3 × 10−37.

Where it sits Chromosome 19, band 19q13.33 — in an intron of SIGLEC11.

What each result means

C/C No copy of the version the research linked to Platelet count. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Platelet count. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Platelet count. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs919777

What is rs919777?

rs919777 is a single position in the genome, in or near the SIGLEC11 gene. Published research associates it with platelet count. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs919777 linked to?

On MyGeneLog this position is linked to Blood Cell Counts. The research behind each link, and its sources, are set out on that condition page.

Does having rs919777 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs919777 come from?

GWAS Catalog, Nature communications 2025, PMID:40436827. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Platelet count (rs919777). MyGeneLog™. https://www.mygenelog.com/variants/rs919777

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