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Asthma

UBAC2 · rs912131

Where this position leads

Condition: Asthma

rs912131 Condition: Asthma Asthma Condition rs912131 rs912131 UBAC2

What the study found

Who was studied 41,926 European ancestry cases, 239,773 European ancestry controls; replicated in 10,365 cases, 16,100 controls.

The effect The reported allele is A; the catalogue records no effect size ; p = 8 × 10−17.

How common The A allele had a frequency of about 30% in the people studied.

Where it sits Chromosome 13, band 13q32.3 — in an intron of UBAC2.

What each result means

A/A Two copies of the version the research linked to Asthma. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Asthma. That is a smaller link than two copies.
G/G No copy of the version the research linked to Asthma. This is the starting point the study compared everyone against.
Source
Genome-wide association analysis of 350 000 Caucasians from the UK Biobank identifies novel loci for asthma, hay fever and eczema
Johansson Å, Rask-Andersen M, Karlsson T, Ek WE
Human molecular genetics · 2019 · PMID 31361310 · open access

Questions about rs912131

What is rs912131?

rs912131 is a single position in the genome, in or near the UBAC2 gene. Published research associates it with asthma. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs912131 linked to?

On MyGeneLog this position is linked to Asthma. The research behind each link, and its sources, are set out on that condition page.

Does having rs912131 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs912131 come from?

GWAS Catalog, Human molecular genetics 2019, PMID:31361310. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Asthma (rs912131). MyGeneLog™. https://www.mygenelog.com/variants/rs912131

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