Standard

Birth length

DCST2 · rs905938

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 28,459 European ancestry individuals; replicated in 16,145 European ancestry individuals, 280 Moroccan ancestry individuals, 284 Surinamese ancestry individuals, 319 Turkish ancestry individuals, 651 Chinese ancestry individuals.

The effect Each copy of the C allele shifted the measure 0.046 higher (95% confidence interval 0.030-0.062); p = 2 × 10⁻⁸.

How common The C allele had a frequency of about 24% in the people studied.

Where it sits Chromosome 1, band 1q21.3 — in an intron of DCST2.

What each result means

C/C Two copies of the version the research linked to Birth length. That is the strongest link of the three results. A link in a study is not a diagnosis.

C/T One copy of the version the research linked to Birth length. That is a smaller link than two copies.

T/T No copy of the version the research linked to Birth length. This is the starting point the study compared everyone against.

Source

A novel common variant in DCST2 is associated with length in early life and height in adulthood

van der Valk RJ, Kreiner-Møller E, Kooijman MN, Guxens M, Stergiakouli E, Sääf A, Bradfield JP, Geller F, Hayes MG, Cousminer DL, Körner A, Thiering E

and 105 more — show all

Curtin JA, Myhre R, Huikari V, Joro R, Kerkhof M, Warrington NM, Pitkänen N, Ntalla I, Horikoshi M, Veijola R, Freathy RM, Teo YY, Barton SJ, Evans DM, Kemp JP, St Pourcain B, Ring SM, Davey Smith G, Bergström A, Kull I, Hakonarson H, Mentch FD, Bisgaard H, Chawes B, Stokholm J, Waage J, Eriksen P, Sevelsted A, Melbye M, van Duijn CM, Medina-Gomez C, Hofman A, de Jongste JC, Taal HR, Uitterlinden AG, Armstrong LL, Eriksson J, Palotie A, Bustamante M, Estivill X, Gonzalez JR, Llop S, Kiess W, Mahajan A, Flexeder C, Tiesler CM, Murray CS, Simpson A, Magnus P, Sengpiel V, Hartikainen AL, Keinanen-Kiukaanniemi S, Lewin A, Da Silva Couto Alves A, Blakemore AI, Buxton JL, Kaakinen M, Rodriguez A, Sebert S, Vaarasmaki M, Lakka T, Lindi V, Gehring U, Postma DS, Ang W, Newnham JP, Lyytikäinen LP, Pahkala K, Raitakari OT, Panoutsopoulou K, Zeggini E, Boomsma DI, Groen-Blokhuis M, Ilonen J, Franke L, Hirschhorn JN, Pers TH, Liang L, Huang J, Hocher B, Knip M, Saw SM, Holloway JW, Melén E, Grant SF, Feenstra B, Lowe WL, Widén E, Sergeyev E, Grallert H, Custovic A, Jacobsson B, Jarvelin MR, Atalay M, Koppelman GH, Pennell CE, Niinikoski H, Dedoussis GV, Mccarthy MI, Frayling TM, Sunyer J, Timpson NJ, Rivadeneira F, Bønnelykke K, Jaddoe VW

Early Genetics and Lifecourse Epidemiology (EAGLE) Consortium · Genetic Investigation of ANthropometric Traits (GIANT) Consortium · Early Growth Genetics (EGG) Consortium

Human molecular genetics · 2015 · PMID 25281659 · open access

Questions about rs905938

What is rs905938?

rs905938 is a single position in the genome, in or near the DCST2 gene. Published research associates it with birth length. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs905938 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs905938 come from?

GWAS Catalog, Hum Mol Genet 2014, PMID:25281659. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Birth length (rs905938). MyGeneLog™. https://www.mygenelog.com/variants/rs905938

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