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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 199 Shetland Isles origin ancestry individuals.
The effect
Each copy of the A allele shifted the measure 1.14 lower (95% confidence interval 0.98-1.29); p = 1 × 10−37.
Where it sits Chromosome 1, band 1q32.1 — between genes, 0.4 kb from CHI3L1.
What each result means
A/ATwo copies of the version the research linked to SMAD5 protein levels (SomaScan ID:11104-13). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to SMAD5 protein levels (SomaScan ID:11104-13). That is a smaller link than two copies.
G/GNo copy of the version the research linked to SMAD5 protein levels (SomaScan ID:11104-13). This is the starting point the study compared everyone against.
Communications biology · 2025 · PMID 40883583 · open access
Questions about rs903357
What is rs903357?
rs903357 is a single position in the genome, in or near the near CHI3L1 gene. Published research associates it with smad5 protein levels (somascan id:11104-13). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs903357 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs903357 come from?
GWAS Catalog, Communications biology 2025, PMID:40883583. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
SMAD5 protein levels (SomaScan ID:11104-13) (rs903357). MyGeneLog™. https://www.mygenelog.com/variants/rs903357