Sensitive

Alzheimer's disease or family history of Alzheimer's disease

TRAF4 · rs902214963

Where this position leads

Condition: Alzheimer's Disease

rs902214963 Condition: Alzheimer's Disease Alzheimer's Disease Condition rs902214963 rs902214963 TRAF4

What the study found

Who was studied 37,075 European, African, Admixed American, Asian, Middle Eastern, Oceanic or unknown ancestry cases, 367,392 European, African, Admixed American, Asian, Middle Eastern, Oceanic or unknown ancestry controls.

The effect The reported allele is C; the catalogue records no effect size ; p = 4 × 10−9.

Where it sits Chromosome 17, band 17q11.2 — in an intron of FAM222B.

What each result means

C/C Two copies of the version the research linked to Alzheimer's disease or family history of Alzheimer's disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/T One copy of the version the research linked to Alzheimer's disease or family history of Alzheimer's disease. That is a smaller link than two copies.
T/T No copy of the version the research linked to Alzheimer's disease or family history of Alzheimer's disease. This is the starting point the study compared everyone against.
Source

Questions about rs902214963

What is rs902214963?

rs902214963 is a single position in the genome, in or near the TRAF4 gene. Published research associates it with alzheimer's disease or family history of alzheimer's disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs902214963 linked to?

On MyGeneLog this position is linked to Alzheimer's Disease. The research behind each link, and its sources, are set out on that condition page.

Does having rs902214963 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs902214963 come from?

GWAS Catalog, Alzheimer's & dementia : the journal of the Alzheimer's Association 2025, PMID:39998322. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Alzheimer's disease or family history of Alzheimer's disease (rs902214963). MyGeneLog™. https://www.mygenelog.com/variants/rs902214963

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