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Urate levels (BMI interaction)

RBFOX3 · rs898534

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied up to 15,007 European ancestry male individuals, up to 16,943 European ancestry female individuals.

The effect Each copy of the G allele shifted the measure 0.0168 lower (95% confidence interval 0.0098-0.0237); p = 2 × 10⁻⁶.

How common The G allele had a frequency of about 88% in the people studied.

Where it sits Chromosome 17, band 17q25.3 — in an intron of RBFOX3.

What each result means

A/A No copy of the version the research linked to Urate levels (BMI interaction). This is the starting point the study compared everyone against.

A/G One copy of the version the research linked to Urate levels (BMI interaction). That is a smaller link than two copies.

G/G Two copies of the version the research linked to Urate levels (BMI interaction). That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

Modulation of genetic associations with serum urate levels by body-mass-index in humans

Huffman JE, Albrecht E, Teumer A, Mangino M, Kapur K, Johnson T, Kutalik Z, Pirastu N, Pistis G, Lopez LM, Haller T, Salo P

and 108 more — show all

Goel A, Li M, Tanaka T, Dehghan A, Ruggiero D, Malerba G, Smith AV, Nolte IM, Portas L, Phipps-Green A, Boteva L, Navarro P, Johansson A, Hicks AA, Polasek O, Esko T, Peden JF, Harris SE, Murgia F, Wild SH, Tenesa A, Tin A, Mihailov E, Grotevendt A, Gislason GK, Coresh J, D'Adamo P, Ulivi S, Vollenweider P, Waeber G, Campbell S, Kolcic I, Fisher K, Viigimaa M, Metter JE, Masciullo C, Trabetti E, Bombieri C, Sorice R, Döring A, Reischl E, Strauch K, Hofman A, Uitterlinden AG, Waldenberger M, Wichmann HE, Davies G, Gow AJ, Dalbeth N, Stamp L, Smit JH, Kirin M, Nagaraja R, Nauck M, Schurmann C, Budde K, Farrington SM, Theodoratou E, Jula A, Salomaa V, Sala C, Hengstenberg C, Burnier M, Mägi R, Klopp N, Kloiber S, Schipf S, Ripatti S, Cabras S, Soranzo N, Homuth G, Nutile T, Munroe PB, Hastie N, Campbell H, Rudan I, Cabrera C, Haley C, Franco OH, Merriman TR, Gudnason V, Pirastu M, Penninx BW, Snieder H, Metspalu A, Ciullo M, Pramstaller PP, van Duijn CM, Ferrucci L, Gambaro G, Deary IJ, Dunlop MG, Wilson JF, Gasparini P, Gyllensten U, Spector TD, Wright AF, Hayward C, Watkins H, Perola M, Bochud M, Kao WH, Caulfield M, Toniolo D, Völzke H, Gieger C, Köttgen A, Vitart V

PloS one · 2015 · PMID 25811787 · open access

Questions about rs898534

What is rs898534?

rs898534 is a single position in the genome, in or near the RBFOX3 gene. Published research associates it with urate levels (bmi interaction). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs898534 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs898534 come from?

GWAS Catalog, PLoS One 2015, PMID:25811787. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Urate levels (BMI interaction) (rs898534). MyGeneLog™. https://www.mygenelog.com/variants/rs898534

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