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Who was studied 5 Hutterite (founder/genetic isolate) cases, 26 Hutterite (founder/genetic isolate) controls.
The effect
Each copy of the C allele carried 2.44 times the odds of Alzheimer's disease (95% confidence interval 1.96-3.05); p = 8 × 10−10.
Where it sits Chromosome 12, band 12q12 — in an intron of PRICKLE1.
What each result means
C/CTwo copies of the version the research linked to Alzheimer's disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/GOne copy of the version the research linked to Alzheimer's disease. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Alzheimer's disease. This is the starting point the study compared everyone against.
Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023 · PMID 35770850
Questions about rs896559
What is rs896559?
rs896559 is a single position in the genome, in or near the PRICKLE1 gene. Published research associates it with alzheimer's disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs896559 linked to?
On MyGeneLog this position is linked to Alzheimer's Disease Risk (APOE). The research behind each link, and its sources, are set out on that condition page.
Does having rs896559 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs896559 come from?
GWAS Catalog, Alzheimer's & dementia : the journal of the Alzheimer's Association 2023, PMID:35770850. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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