Cisplatin-induced hearing loss in childhood cancer
TCERG1L · rs893507
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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 168 European ancestry, African American or Afro-Caribbean, Hispanic or Latin American child cases, 222 European, African American or Afro-Caribbean, Hispanic or Latin American ancestry child controls; replicated in 209 child cases, 171 child controls.
The effect
Each copy of the C allele carried 3.11 times the odds of Cisplatin-induced hearing loss in childhood cancer (95% confidence interval 2.2-4.5); p = 5 × 10−10.
How common The C allele had a frequency of about 15% in the people studied.
Where it sits Chromosome 10, band 10q26.3 — in an intron of TCERG1L.
What each result means
C/CTwo copies of the version the research linked to Cisplatin-induced hearing loss in childhood cancer. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Cisplatin-induced hearing loss in childhood cancer. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Cisplatin-induced hearing loss in childhood cancer. This is the starting point the study compared everyone against.
rs893507 is a single position in the genome, in or near the TCERG1L gene. Published research associates it with cisplatin-induced hearing loss in childhood cancer. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs893507 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs893507 come from?
GWAS Catalog, NPJ precision oncology 2021, PMID:34262104. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
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Cisplatin-induced hearing loss in childhood cancer (rs893507). MyGeneLog™. https://www.mygenelog.com/variants/rs893507